After a young man's premonition of a deadly race-car crash helps saves the lives of his peers, Death sets out to collect those who evaded their end.
Tony Lip, a bouncer in 1962, is hired to drive pianist Don Shirley on a tour through the Deep South in the days when African Americans, forced to find alternate accommodations and services due to segregation laws below the Mason-Dixon Line, relied on a guide called The Negro Motorist Green Book.
President Lincoln's mother is killed by a supernatural creature, which fuels his passion to crush vampires and their slave-owning helpers.